Studies from around the world by leading researchers show that Juice Plus+® positively impacts several key indicators of cardiovascular wellness


University of Maryland

 Plotnick et al. Journal of the American College of Cardiology, 2003

Study summary and findings:

This double-blind, placebo-controlled, randomized parallel group study determined if three to four weeks of daily Juice Plus+ or placebo consumption could prevent the immediate reduction of flow-mediated vasodilation caused by a high-fat meal. Thirty-eight healthy American volunteers took part in the study. Subjects were randomized groups to take Juice Plus+ Orchard Blend and Garden Blend, Juice Plus+ Orchard Blend, Garden Blend and Vineyard Blend, or placebo daily for 28 days. The flow-mediated brachial artery reactivity test (BART) was used at baseline, day 21 (end of week 3) and day 28 (end of week 4), both before and after a high fat (50 gram), 900 calorie meal, to measure vasoconstriction. Fasting blood samples for analysis were collected at the beginning and end of the study. After both 21 and 28 days, the Juice Plus+ groups showed a reduction in the detrimental effect of the high fat meal on vascular function. The addition of Vineyard Blend to the regimen of Orchard and Garden Blend had an additional positive influence on this parameter. The Juice Plus+ groups also had a modest decrease in total and LDL cholesterol and no change in HDL cholesterol or triglycerides compared to the placebo group. The entire study population had low baseline homocysteine, which remained unchanged in during the investigation.

Complete Article: Journal of the American College of Cardiology, 2003; 41 (10): 1744-1749


Vanderbilt University

Houston et al. eCAM, 2007

Study summary and findings:

Researchers followed 51 hypertensive (on stable medication) and pre-hypertensive adults asymptomatic for heart disease over two years taking Juice Plus+ Orchard, Garden and Vineyard Blends. The participants were primarily male (80%) with an average age of 61 years. They followed their habitual diet, exercise program, and other lifestyle behaviors and experienced no change in body weight. By the end of follow-up, both systolic and diastolic blood pressure decreased; large artery compliance improved; and, progression of coronary calcium score was smaller than expected. Very small changes in blood lipids - including a reduction in triglycerides and HDL-cholesterol and an increase in total cholesterol and LDL-cholesterol - were observed. Folate, beta-carotene, Co-Q10, and alpha-tocopherol increased. Both glycated hemoglobin and homocysteine decreased.

´╗┐Abstract and complete Article: eCAM, 2007; 4:455-462


University of Sydney, Australia

Samman et al. Journal of Nutrition, 2003

Study summary and findings:

This study measured the effect Juice Plus+ on plasma levels of selected vitamins, recognized coronary heart disease (CHD) risk factors, and general antioxidant status. Thirty- two healthy Australian men participated in this double-blind, placebo-controlled randomized crossover trial, consisting of two intervention periods of six weeks each, separated by a three week wash-out phase. During the intervention periods, subjects took either Juice Plus+ or placebo. Blood samples for nutrient analysis of and plasma antioxidant capacity were obtained at baseline, and again at the end of the third and sixth week for each intervention period. Plasma folate, vitamin C, alpha-tocopherol (vitamin E), retinol, and beta-carotene all increased significantly during the Juice Plus+ intervention period compared to placebo period. There was a trend (p = 0.065) for increased plasma antioxidant capacity, and a significant reduction in homocysteine during the Juice Plus+ intervention period.

Abstrace and complete Article: Journal of Nutrition, 2003; 133 (7): 2188-2193


Foggia Italy Study

Panunzio et al. Nutrition Research 2003 Foggia

Study summary and findings:

This study showed Juice Plus+ use led to a reduction in plasma homocysteine concentration. Twenty-six healthy Italian subjects (12 men and 14 women) aged 20-56 years, took part in this randomized, crossover study. The trial was separated into three phases of four weeks each: an initial treatment period, a washout period and a second treatment period. Folate level increased and homocysteine level decreased significantly in both groups while taking the Juice Plus+ capsules, but not during the control period of this study.

Article Abstract: Nutrition Research, 2003; 23 (9): 1221-1228


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